Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab.

Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.

Individual Reaction Mix 3

G065-3 200 reactions
EUR 167

3-D Life Thioglycerol

T10-3 180 µl
EUR 48

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

3-D-Life SG-PVA

M81-3 3x 170 µl
EUR 148

3-D Life FG-PVA

M82-3 3x 170 µl
EUR 148

3-D Life SG-Dextran

M91-3 3x 170 µl
EUR 157

3-D Life FG-Dextran

M92-3 3x 170 µl
EUR 157

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D Life RGD Peptide

P10-3 3x 1 µmol
EUR 276

Dr. P Kit-Solution 3

K2021010-3 50 ml
EUR 133
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

3-D Life PEG-Link

L50-3 3x 200 µl
EUR 94

3-D Life CD-Link

L60-3 3 x 200 µl
EUR 321

pLenti-CARM1 shRNA-3 Plasmid

PVTBAV03691-3 2 ug
EUR 356

pLenti-CTLA4 shRNA-3 Plasmid

PVTBAV05689-3 2 ug
EUR 356

pLenti-FOXM1 shRNA-3 Plasmid

PVTBAV08732-3 2 ug
EUR 356

pLenti-JUN shRNA-3 Plasmid

PVTBAV11741-3 2 ug
EUR 356

pLenti-LHX6 shRNA-3 Plasmid

PVTBAV12881-3 2 ug
EUR 356

pLenti-MAGEA3 shRNA-3 Plasmid

PVTBAV13661-3 2 ug
EUR 356

pLenti-RUNX3 shRNA-3 Plasmid

PVTBAV20583-3 2 ug
EUR 356

pLenti-Slc7a11 shRNA-3 Plasmid

PVTBAV21973-3 2 ug
EUR 356

pLenti-STAT3 shRNA-3 Plasmid

PVTBAV22921-3 2 ug
EUR 356

FSH (Human Follicle-stimulating hormone) ELISA test

3 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone)

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334

Caspase-3 Inhibitor Q-DEVD-OPh

1175-3
EUR 533

3-D Life Scrambled RGD Peptide

P11-3 3x 1 µmol
EUR 276

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12)

M00621-3 100ug/vial
EUR 334

QuantiMir 3'-Universal Primer (10,000 qPCR reactions)

RA420AU-3 10,000 assays
EUR 178
  • Category: MicroRNA Tools

SeraMir 3'-Universal Primer (10,000 qPCR reactions)

RA800P-3 10,000 reactions
EUR 178
  • Category: MicroRNA Tools

3-D Life 10x CB-Buffer (pH 5.5)

B10-3 600 µl
EUR 44

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3 1KIT
EUR 809
Description: Minimum order quantity: 1 unit of 1KIT

3-D Life 10x CB Buffer (pH 7.2)

B20-3 600 µL
EUR 44

Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody

M00227-3 100ul
EUR 397
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine.

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3
EUR 441

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3
EUR 436

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 436

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 436

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3
EUR 332

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3
EUR 430

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3
EUR 430

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3
EUR 430

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3
EUR 436

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-3 Regular: 10ug
EUR 317
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

Lethal factor Protease Substrate 3, AMC derivative MEk2 peptide substrate for high-throughput screening of LF inhibitors (14aa)

LFPS-3 1 mg
EUR 408

Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #3)

PEG13-M-3 100 ug
EUR 482

Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #3)

CDTA12-M-3 100 ug
EUR 482

ABC diluent buffer

AR1106-3 12ml
EUR 91

Calcein AM, (20x50ug)

80011-3 20ST
EUR 242
Description: Minimum order quantity: 1 unit of 20ST

Antibody analysis - human >30 samples

8005-3 Custom service
EUR 113.8
Description: Antibody analysis - human >30 samples

Anti-IFNAR2 Antibody

A02056-3 100ug/vial
EUR 334

Anti-IL17F Antibody

A02062-3 100ug/vial
EUR 294

Anti-TREM1 Antibody

A02135-3 100ug/vial
EUR 294

Anti-SENP1 Antibody

A02156-3 100ug/vial
EUR 294

Anti-BTC Antibody

A02171-3 100ug/vial
EUR 334

Anti-EEA1 Antibody

A02296-3 100ug/vial
EUR 294

Anti-Dishevelled 2/DVL2 Antibody

A02404-3 100ug/vial
EUR 294

Anti-Alpha 1 microglobulin/AMBP Antibody

A02419-3 100ug/vial
EUR 334

Anti-NRAMP1/SLC11A1 Antibody

A02547-3 100ug/vial
EUR 334

Anti-CD13/Anpep Antibody

A02591-3 100ug/vial
EUR 334

Anti-JAK3 Antibody

A02598-3 100ug/vial
EUR 294

Anti-HE4/Wfdc2 Antibody

A02685-3 100ug/vial
EUR 334

Anti-APRT Antibody

A02721-3 100ug/vial
EUR 334

Anti-B7H4/VTCN1 Antibody

A02821-3 100ug/vial
EUR 294

Anti-CUL2 Antibody

A02986-3 100ug/vial
EUR 334

Anti-Scramblase 1/Plscr1 Antibody

A02995-3 100ug/vial
EUR 334

Anti-GITR/Tnfrsf18 Antibody

A03125-3 100ug/vial
EUR 294

Anti-Thrombopoietin/THPO Antibody

A03222-3 100ug/vial
EUR 294

Anti-XLF/NHEJ1 Antibody

A03552-3 100ug/vial
EUR 334

Anti-HIF3/HIF3A Antibody

A03805-3 100ug/vial
EUR 294

Anti-EIF4A1 Antibody

A03922-3 100ug/vial
EUR 334

Anti-SLIT1 Antibody

A04113-3 100ug/vial
EUR 294

Anti-SORBS1 Antibody

A04426-3 100ug/vial
EUR 334

Anti-RNF31/HOIP Antibody

A04457-3 100ug/vial
EUR 294

Anti-VEGFB Antibody

A04494-3 100ug/vial
EUR 294

Anti-Aldolase/ALDOA Antibody

A05022-3 100ug/vial
EUR 334

Anti-SENP6 Antibody

A05088-3 100ug/vial
EUR 294

Anti-ZNFN1A2/HELIOS/IKZF2 Antibody

A05228-3 100ug/vial
EUR 294

Anti-TNF alpha Antibody

A00002-3 100ug/vial
EUR 294

Anti-p16 Monoclonal Antibody

A00016-3 100ul
EUR 397
Description: Mouse Monoclonal Antibody for p16 Antibody (CDKN2A) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-APP/C99 Antibody

A00081-3 100ug/vial
EUR 334

Anti-IL1 beta Antibody

A00101-3 100ug
EUR 455
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat.

Anti-IL-6 Antibody

A00102-3 1mL
EUR 1232
Description: Rabbit Polyclonal IL-6 Antibody. Validated in IP, WB and tested in Human.

Anti-Nanog Antibody

A00153-3 100ug/vial
EUR 294

Anti-IL17C Antibody

A00164-3 100ug/vial
EUR 294

Anti-Flt3/CD135 Antibody

A00188-3 100ug/vial
EUR 334

Anti-Aryl hydrocarbon Receptor/Ahr Antibody

A00225-3 100ug/vial
EUR 294

Anti-CRP Antibody Fluorescein Conjugated

A00249-3 100ug
EUR 455
Description: Goat Polyclonal CRP Antibody Fluorescein Conjugated. Validated in WB and tested in Human.

Anti-BMAL1/ARNTL Antibody

A00260-3 100ug/vial
EUR 294

Anti-AICDA Antibody

A00267-3 100ug/vial
EUR 294

Anti-NFkB-p65 (Ab-276) Antibody

A00284-3 100ul
EUR 397
Description: Rabbit Polyclonal NFkB-p65 (Ab-276) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-ICOS Antibody

A00291-3 100ug/vial
EUR 334

Anti-TNF Receptor I/TNFRSF1A Antibody

A00294-3 100ug/vial
EUR 334

Anti-Interferon gamma/IFNG Antibody

A00393-3 100ug/vial
EUR 334

Anti-TLR1 Antibody

A00429-3 100ug/vial
EUR 334

Anti-IGFBP3 Antibody

A00435-3 100ug/vial
EUR 294

Anti-TANK Antibody

A00445-3 100ug/vial
EUR 334

Anti-beta 2 Microglobulin/B2m Antibody

A00456-3 100ug/vial
EUR 294

Anti-FGF23 Antibody

A00478-3 100ug/vial
EUR 294

Anti-Leptin Antibody

A00479-3 100ug/vial
EUR 294

Anti-CD5 Antibody

A00480-3 100ug/vial
EUR 334

Anti-SYK Antibody

A00490-3 100ug/vial
EUR 294

Anti-PON1 Antibody

A00516-3 100ug/vial
EUR 334

Anti-Cytochrome P450 17A1/Cyp17a1 Antibody

A00615-3 100ug/vial
EUR 334

Anti-CSF1 Antibody

A00620-3 100ug/vial
EUR 294

Anti-Polycystin 2/PKD2 Antibody

A00630-3 100ug/vial
EUR 334

Anti-IL1RA/Il1rn Antibody

A00651-3 100ug/vial
EUR 294

Anti-Smad1 (Ab-465) Antibody

A00728-3 100ul
EUR 397
Description: Rabbit Polyclonal Smad1 (Ab-465) Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-LOX 1/Olr1 Antibody

A00760-3 100ug/vial
EUR 334

Anti-Collagen III/COL3A1 Antibody

A00788-3 100ug/vial
EUR 334

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