Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab.

Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.

Individual Reaction Mix 3

G065-3 200 reactions
EUR 167.00

3-D Life Thioglycerol

T10-3 180 µl
EUR 48.00

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317.00
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

Dr. P Kit-Solution 3

K2021010-3 50 ml
EUR 133.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

pLenti-CARM1 shRNA-3 Plasmid

PVTBAV03691-3 2 ug
EUR 356.00

pLenti-CTLA4 shRNA-3 Plasmid

PVTBAV05689-3 2 ug
EUR 356.00

pLenti-FOXM1 shRNA-3 Plasmid

PVTBAV08732-3 2 ug
EUR 356.00

pLenti-JUN shRNA-3 Plasmid

PVTBAV11741-3 2 ug
EUR 356.00

pLenti-LHX6 shRNA-3 Plasmid

PVTBAV12881-3 2 ug
EUR 356.00

pLenti-MAGEA3 shRNA-3 Plasmid

PVTBAV13661-3 2 ug
EUR 356.00

pLenti-RUNX3 shRNA-3 Plasmid

PVTBAV20583-3 2 ug
EUR 356.00

pLenti-Slc7a11 shRNA-3 Plasmid

PVTBAV21973-3 2 ug
EUR 356.00

pLenti-STAT3 shRNA-3 Plasmid

PVTBAV22921-3 2 ug
EUR 356.00

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317.00
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D Life PEG-Link

L50-3 3x 200 µl
EUR 94.00

3-D Life CD-Link

L60-3 3 x 200 µl
EUR 321.00

3-D-Life SG-PVA

M81-3 3x 170 µl
EUR 148.00

3-D Life FG-PVA

M82-3 3x 170 µl
EUR 148.00

3-D Life SG-Dextran

M91-3 3x 170 µl
EUR 157.00

3-D Life FG-Dextran

M92-3 3x 170 µl
EUR 157.00

3-D Life RGD Peptide

P10-3 3x 1 µmol
EUR 276.00

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334.00

Caspase-3 Inhibitor Q-DEVD-OPh

1175-3
EUR 533.00

3-D Life Scrambled RGD Peptide

P11-3 3x 1 µmol
EUR 276.00

FSH (Human Follicle-stimulating hormone) ELISA test

3 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone)

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397.00
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12)

M00621-3 100ug/vial
EUR 334.00

QuantiMir 3'-Universal Primer (10,000 qPCR reactions)

RA420AU-3 10,000 assays
EUR 178.00
  • Category: MicroRNA Tools

SeraMir 3'-Universal Primer (10,000 qPCR reactions)

RA800P-3 10,000 reactions
EUR 178.00
  • Category: MicroRNA Tools

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3 1KIT
EUR 809.00
Description: Minimum order quantity: 1 unit of 1KIT

Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody

M00227-3 100ul
EUR 397.00
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine.

3-D Life 10x CB-Buffer (pH 5.5)

B10-3 600 µl
EUR 44.00

3-D Life 10x CB Buffer (pH 7.2)

B20-3 600 µL
EUR 44.00

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317.00
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3
EUR 441.00

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3
EUR 436.00

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 436.00

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 436.00

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3
EUR 332.00

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3
EUR 430.00

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3
EUR 430.00

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3
EUR 430.00

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3
EUR 436.00

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-3 Regular: 10ug
EUR 317.00
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

Lethal factor Protease Substrate 3, AMC derivative MEk2 peptide substrate for high-throughput screening of LF inhibitors (14aa)

LFPS-3 1 mg
EUR 408.00

Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #3)

PEG13-M-3 100 ug
EUR 482.00

Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #3)

CDTA12-M-3 100 ug
EUR 482.00

Goat Gamma Globulin

22005-3 50g
EUR 1205.00
  • All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
Description: Goat gamma globulin is purified from serum obtained from normal healthy animals (male and female) by using various fractionation procedures followed by dialysis against low ionic strength buffer. It is in lyophilized powder form with purity of 98% or more. Protein by weight: O.D. 280 nm E1%1.39: ? 85% - Residual salts, lipids, etc. comprise the rest of the weight.

Bovine Serum Sterile, Non-Hemolyzed, Delipidized

37146-3 500mL
EUR 198.00
  • All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
Description: Whole blood is collected from healthy animals of mixed breed both male and female that are 1+ years of age. The blood is refrigerated within 6 hours after collection and is processed within 24 hours and frozen at -20°C. The serum is then thawed in a cool water bath. First the lipids are removed, then the serum is filtered through a 0.22 micron filter. The obtained product is bottled and frozen at -20 ºC.

Horse Serum Non-Sterile, Non-Hemolyzed

39321-3 500mL
EUR 129.00
  • All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
Description: Whole blood is collected from both male and female healthy horses living in a herd and are 1+ years of age. The blood is refrigerated within 6 hours after collection and is processed within 24 hours and frozen at -20°C.

Pig Serum, Non-Sterile, Trace-Hemolyzed

39328-3 3L
EUR 356.00
  • All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
Description: Whole blood is collected from healthy pigs of mixed breed, either sex and fasted at the time of slaughter. The blood is then refrigerated within 6 hours, processed within 24 hours and frozen at -20°C.

Pig Serum, Non-Sterile, Trace-Hemolyzed

39519-3 500mL
EUR 149.00
  • All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
Description: Whole blood is collected from healthy pigs of mixed breed, either sex and fasted at the time of slaughter. The blood is then refrigerated within 6 hours, processed within 24 hours and frozen at -20°C.

Mouse anti-dsDNA IgG3-specific ELISA Kit, 96 tests, Quantitative

5120-3 1 kit
EUR 712.00

TARGATT? attp Mouse B6 (Age: 36-42 days) *Ship from CRL

549-3 1 female Ask for price
Description: N/A

Anti-PYROXD1 Antibody

A17214-3 100ug/vial
EUR 334.00

Anti-Choline Acetyltransferase/CHAT Antibody

A01192-3 100ug/vial
EUR 334.00

Anti-TAPA1/Cd81 Antibody

A01281-3 100ug/vial
EUR 294.00

Anti-TrkB/NTRK2 Antibody

A01388-3 100ug/vial
EUR 294.00

Anti-PRMT1 Antibody

A01417-3 100ug/vial
EUR 294.00

Anti-CD31/Pecam1 Antibody

A01513-3 100ug/vial
EUR 334.00

Anti-Carbonic Anhydrase 4/CA4 Antibody

A01523-3 100ug/vial
EUR 334.00

Anti-Niemann Pick C2/NPC2 Antibody

A01582-3 100ug/vial
EUR 334.00

Anti-Nag-1 Antibody Peroxidase Conjugated

A01583-3 100ug
EUR 455.00
Description: Rabbit Polyclonal Nag-1 Antibody Peroxidase Conjugated. Validated in IHC, WB and tested in Human, Mouse.

Anti-TFF3 Antibody

A01738-3 100ug/vial
EUR 334.00

Anti-Endothelin A Receptor Antibody

A01828-3 250ug
EUR 484.00
Description: Sheep Polyclonal Endothelin A Receptor Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLB1/Beta-galactosidase Antibody

A01829-3 100ug/vial
EUR 334.00

Anti-FPRL1/FPR2 Antibody

A01980-3 100ug/vial
EUR 334.00

Anti-IFNAR2 Antibody

A02056-3 100ug/vial
EUR 334.00

Anti-IL17F Antibody

A02062-3 100ug/vial
EUR 294.00

Anti-TREM1 Antibody

A02135-3 100ug/vial
EUR 294.00

Anti-SENP1 Antibody

A02156-3 100ug/vial
EUR 294.00

Anti-BTC Antibody

A02171-3 100ug/vial
EUR 334.00

Anti-EEA1 Antibody

A02296-3 100ug/vial
EUR 294.00

Anti-Dishevelled 2/DVL2 Antibody

A02404-3 100ug/vial
EUR 294.00

Anti-Alpha 1 microglobulin/AMBP Antibody

A02419-3 100ug/vial
EUR 334.00

Anti-NRAMP1/SLC11A1 Antibody

A02547-3 100ug/vial
EUR 334.00

Anti-CD13/Anpep Antibody

A02591-3 100ug/vial
EUR 334.00

Anti-JAK3 Antibody

A02598-3 100ug/vial
EUR 294.00

Anti-HE4/Wfdc2 Antibody

A02685-3 100ug/vial
EUR 334.00

Anti-APRT Antibody

A02721-3 100ug/vial
EUR 334.00

Anti-B7H4/VTCN1 Antibody

A02821-3 100ug/vial
EUR 294.00

Anti-CUL2 Antibody

A02986-3 100ug/vial
EUR 334.00

Anti-Scramblase 1/Plscr1 Antibody

A02995-3 100ug/vial
EUR 334.00

Anti-GITR/Tnfrsf18 Antibody

A03125-3 100ug/vial
EUR 294.00

Anti-Thrombopoietin/THPO Antibody

A03222-3 100ug/vial
EUR 294.00

Anti-XLF/NHEJ1 Antibody

A03552-3 100ug/vial
EUR 334.00

Anti-HIF3/HIF3A Antibody

A03805-3 100ug/vial
EUR 294.00

Anti-EIF4A1 Antibody

A03922-3 100ug/vial
EUR 334.00

Anti-SLIT1 Antibody

A04113-3 100ug/vial
EUR 294.00

Anti-SORBS1 Antibody

A04426-3 100ug/vial
EUR 334.00

Anti-RNF31/HOIP Antibody

A04457-3 100ug/vial
EUR 294.00

Anti-VEGFB Antibody

A04494-3 100ug/vial
EUR 294.00

Anti-Aldolase/ALDOA Antibody

A05022-3 100ug/vial
EUR 334.00

Anti-SENP6 Antibody

A05088-3 100ug/vial
EUR 294.00

Anti-ZNFN1A2/HELIOS/IKZF2 Antibody

A05228-3 100ug/vial
EUR 294.00

Anti-RAB3GAP2 Antibody

A07244-3 100ug/vial
EUR 334.00

Anti-FOXI1 Antibody

A07512-3 100ug/vial
EUR 334.00

Anti-IL36 alpha/IL36A Antibody

A09802-3 100ug/vial
EUR 334.00

Anti-IL17B Antibody

A10846-3 100ug/vial
EUR 294.00

Anti-RBMS3 Antibody

A12416-3 100ug/vial
EUR 334.00

Anti-TNF alpha Antibody

A00002-3 100ug/vial
EUR 294.00

Anti-p16 Monoclonal Antibody

A00016-3 100ul
EUR 397.00
Description: Mouse Monoclonal Antibody for p16 Antibody (CDKN2A) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-APP/C99 Antibody

A00081-3 100ug/vial
EUR 334.00

Anti-IL1 beta Antibody

A00101-3 100ug
EUR 455.00
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat.

Anti-IL-6 Antibody

A00102-3 1mL
EUR 1232.00
Description: Rabbit Polyclonal IL-6 Antibody. Validated in IP, WB and tested in Human.

Anti-Nanog Antibody

A00153-3 100ug/vial
EUR 294.00

Anti-IL17C Antibody

A00164-3 100ug/vial
EUR 294.00

Anti-Flt3/CD135 Antibody

A00188-3 100ug/vial
EUR 334.00

Anti-Aryl hydrocarbon Receptor/Ahr Antibody

A00225-3 100ug/vial
EUR 294.00

Anti-CRP Antibody Fluorescein Conjugated

A00249-3 100ug
EUR 455.00
Description: Goat Polyclonal CRP Antibody Fluorescein Conjugated. Validated in WB and tested in Human.

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