NTO 7160 was generally well tolerated, with one serious adverse event of severe cellulitis reported (AD, CNTO 7160 3 mg kg-1 ). CNTO 7160 exhibited non-linear PK (0.01 to 10 mg kg-1 ). Mean clearance decreased with increasing dose (2.43 to 18.03 mL day-1 kg-1 ). CNTO 7160 PK was similar between healthy subjects and patients with asthma or AD (3 or 10 mg kg-1 ). Free sIL-33R suppression was rapid and dose-dependent. Ex-vivo inhibition of p38 phosphorylation of basophils was dose-dependent (1 to 10 mg kg-1 ) and sustained inhibition (≥75%) was observed at higher doses (3 or 10 mg kg-1 ). PK/PD modelling and simulation suggests that 1 mg/kg IV every 2 weeks provides adequate systemic drug exposure for sustained inhibition of p38 phosphorylation of basophils.

Despite confirmation of target engagement, no apparent CNTO 7160 clinical activity was observed in patients (asthma or AD).This first-in-human study provides PK, PD, and safety data, supporting further clinical investigation of CNTO 7160 in patients with asthma and AD.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Mouse FibrOut 4, for brain, neural

4-20507 1 ml Ask for price

Mouse FibrOut 4, for brain, neural

4-20508 5 x 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20533 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20534 5 x 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 120V

6780-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Bone Dissociation System 4 (Osteoblasts), Adult Mouse

4-20214 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse

4-20404 ea Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat

4-20444 ea Ask for price

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat

4-20234 ea Ask for price

Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse

4-20324 ea Ask for price

Pancreas Dissociation System 4 (Islets), Mouse and Rat

4-20374 ea Ask for price

Skin Dissociation System 4 (Keratinocytes), Mouse and Rat

4-20434 ea Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG

6781-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG

6782-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Adipose/Fat Dissociation System 4 (Predipocytes), Mouse and Rat

4-20194 ea Ask for price

Brain Dissociation System 4 (Endothelial, Microvessels), Mouse and Rat

4-20224 ea Ask for price

Endothelial Dissociation System 4 (Endothelial,Cerebral), Mouse and Rat

4-20244 ea Ask for price

Heart Dissociation System 4 (Myocytes,Ventricles), Mouse and Rat

4-20274 ea Ask for price

Muscle Dissociation System 4 (Smooth muscle), Mouse and Rat

4-20334 ea Ask for price

Parotid Dissociation System 4 (Parotid acinar), Mouse and Rat

4-20394 ea Ask for price

Epithelial Dissociation System 4 (Epithelial,Submandibular salivary), Mouse and Rat

4-20254 ea Ask for price

Heart Dissociation System 4 (Retinal pigment epithelial), Mouse and Rat

4-20294 ea Ask for price

Lung Dissociation System 4 (Alveolar type II), Mouse and Rat

4-20314 ea Ask for price

Reproductive Tissue Dissociation System 4 (Epithelial, vagina), Mouse and Rat

4-20414 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials)

M1040-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials)

M1041-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials)

M1042-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials)

M1043-4
EUR 1132

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials)

M1046-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials)

M1047-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 4 vials)

M1054-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 4 vials)

M1055-4
EUR 1142

Adrenal Dissociation System 4 (Heart, Adrenal chromaffin, Paraneurons), Mouse and Rat

4-20204 ea Ask for price

Kidney Dissociation System 4 (Inner medullary duct,Papillae), Mouse and Rat

4-29294 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 4 vials)

M1048-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 4 vials)

M1049-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 4 vials)

M1050-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 4 vials)

M1051-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 4 vials)

M1052-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 4 vials)

M1053-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 4 vials)

M1058-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 4 vials)

M1059-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 4 vials)

M1060-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 4 vials)

M1061-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 4 vials)

M1064-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 4 vials)

M1065-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 4 vials)

M1066-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 4 vials)

M1067-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 4 vials)

M1070-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, B16F10 cell line, 4 vials)

M1071-4
EUR 1142

Tumor Dissociation System 4 (Epithelial tumor,Neoplastic, Tumor, islet), Mouse and Rat

4-20484 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 4 vials)

M1062-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 4 vials)

M1063-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 4 vials)

M1068-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 4 vials)

M1069-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, SK-N-SH cell line, 4 vials)

M1056-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, SK-N-SH cell line, 4 vials)

M1057-4
EUR 1142

Neural Dissociation System 4 (Cerebella neurons Dorsa horn neurons Neurons, sympathetic Precursor Spinal), Mouse and Rat

4-20354 ea Ask for price

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

DLR-CA72-4-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

DLR-CA72-4-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RD-CA72-4-Hu-48Tests 48 Tests
EUR 478

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RD-CA72-4-Hu-96Tests 96 Tests
EUR 662

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RDR-CA72-4-Hu-48Tests 48 Tests
EUR 500

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RDR-CA72-4-Hu-96Tests 96 Tests
EUR 692

PRL (Prolactin) ELISA test

4 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PRL (Prolactin)

Anti-p53 Monoclonal Antibody (PAb122)

M00001-4 200ug
EUR 511
Description: Mouse Monoclonal p53 Antibody (PAb122). Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-AKT (PH domain) Rabbit Monoclonal Antibody, Clone#RM316

M00024-4 100uL
EUR 385
Description: Anti-AKT (PH domain) Rabbit Monoclonal Antibody, Clone#RM316 tested in WB, IHC, reactive to Human

Anti-CDK1/Cdc2 Rabbit Monoclonal Antibody

M00209-4 100ug/vial
EUR 397
Description: Anti-CDK1 Rabbit Monoclonal Antibodytested for IP, IF, IHC, ICC, WB in Human, Mouse, Rat

Anti-GAPDH Antibody

M00227-4 100ul
EUR 397
Description: Rabbit Polyclonal GAPDH Antibody. Validated in IF, IHC, WB and tested in Bovine, Chicken, Equine, Human, Mouse, Pig, Rat.

Anti-Vimentin Antibody

M00235-4 100ul
EUR 397
Description: Rabbit Polyclonal Vimentin Antibody. Validated in IHC, WB and tested in Bovine, Equine, Human, Mouse, Pig, Rat.

Anti-Aurora A Kinase Monoclonal Antibody

M00246-4 100ul
EUR 397
Description: Mouse Monoclonal Aurora A Kinase Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Ki-67 Antibody

M00254-4 100ul
EUR 397
Description: Chicken Polyclonal Ki-67 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-C-FOS Antibody

M00297-4 100ul
EUR 397
Description: Rabbit Polyclonal C-FOS Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-active + pro Caspase 3 Rabbit Monoclonal Antibody

M00334-4 100ug/vial
EUR 397
Description: Rabbit Monoclonal active + pro Caspase 3 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

Anti-Thyroglobulin Monoclonal Antibody

M00359-4 100ug
EUR 397
Description: Rabbit Monoclonal Thyroglobulin Antibody. Validated in IP, IF, WB and tested in Human.

Anti-CK-5/CK-6 (Cytokeratin 5/ Cytokeratin 6) Rabbit Monoclonal Antibody, Clone#RM341

M00398-4 100uL
EUR 385
Description: Anti-CK-5/CK-6 (Cytokeratin 5/ Cytokeratin 6) Rabbit Monoclonal Antibody, Clone#RM341 tested in WB, IHC, reactive to Human

Anti-AR (N-terminal) Rabbit Monoclonal Antibody, Clone#RM254

M00542-4 100uL
EUR 427
Description: Anti-AR (N-terminal) Rabbit Monoclonal Antibody, Clone#RM254 tested in WB, IHC, reactive to Human

Anti-HSP27 Monoclonal Antibody

M00676-4 200ug
EUR 397
Description: Mouse Monoclonal HSP27 Antibody. Validated in ELISA, IP, IF, WB and tested in Human.

Anti-Cyclin B1 Rabbit Monoclonal Antibody, Clone#RM281

M00745-4 100uL
EUR 375
Description: Anti-Cyclin B1 Rabbit Monoclonal Antibody, Clone#RM281 tested in WB, IHC, reactive to Human

Anti-ZAP70 Antibody (monoclonal, 6F12)

M00754-4 100ug/vial
EUR 294

Anti-Aurora-B (AURKB) Rabbit Monoclonal Antibody, Clone#RM278

M00762-4 100uL
EUR 375
Description: Anti-Aurora-B (AURKB) Rabbit Monoclonal Antibody, Clone#RM278 tested in WB, IHC, reactive to Human

Anti-ACTA2 Rabbit Monoclonal Antibody, Clone#RM253

M01072-4 100ul
EUR 375
Description: Anti-ACTA2 Rabbit Monoclonal Antibody, Clone#RM253 tested in WB, IHC, reactive to Human, Mouse, (Bovine, Rat)

Anti-Cytokeratin 18 Antibody (monoclonal, 7I6)

M01357-4 100ug/vial
EUR 334

Anti-CK8 (Cytokeratin-8) Rabbit Monoclonal Antibody, Clone#RM266

M01421-4 100uL
EUR 375
Description: Anti-CK8 (Cytokeratin-8) Rabbit Monoclonal Antibody, Clone#RM266 tested in WB, IHC, reactive to Human

Anti-GAP43 Antibody

M01868-4 100ul
EUR 397
Description: Chicken Polyclonal GAP43 Antibody. Validated in IF, IHC, WB and tested in Bovine, Chicken, Equine, Human, Mouse, Pig, Rat.

Anti-Actin (Alpha-Actin) Rabbit Monoclonal Antibody

M02014-4 100ug/vial
EUR 397
Description: Rabbit Monoclonal Actin (Alpha-Actin) Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Anti-Cytokeratin 19 (CK-19) Rabbit Monoclonal Antibody, Clone#RM364

M02101-4 100uL
EUR 385
Description: Anti-Cytokeratin 19 (CK-19) Rabbit Monoclonal Antibody, Clone#RM364 tested in WB, IHC, reactive to Human

Anti-Neurofilament Light Chain NF-L Antibody

M02482-4 100ul
EUR 397
Description: Chicken Polyclonal Neurofilament Light Chain NF-L Antibody. Validated in IHC, WB and tested in Bovine, Human, Mouse, Pig, Rat.

Anti-Ubiquitin Monoclonal Antibody

M02848-4 100ul
EUR 397
Description: Mouse Monoclonal Ubiquitin Antibody. Validated in IHC, WB and tested in Bovine, C. Elegans, Chicken, Drosophila, Equine, Mouse, Pig.