Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab.

Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.

HaP-T1
ABC-TC039S 1 vial Ask for price
Description: Cancer; Lifespan: infinite; Mucin producing, BHP-induced pancreatic tumor.

OAAV00052-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00052-200UG 200ug
EUR 459

OAAV00053-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00053-200UG 200ug
EUR 459

OAAV00054-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00054-200UG 200ug
EUR 459

OAAV00055-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00055-200UG 200ug
EUR 459

OAAV00056-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00056-200UG 200ug
EUR 459

OAAV00057-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00057-200UG 200ug
EUR 459

OAAV00058-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00058-200UG 200ug
EUR 459

OAAV00059-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00059-200UG 200ug
EUR 459

OAAV00060-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00060-200UG 200ug
EUR 459

OAAV00061-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00061-200UG 200ug
EUR 459

OAAV00062-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00062-200UG 200ug
EUR 459

OAAV00063-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00063-200UG 200ug
EUR 459

OAAV00064-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00064-200UG 200ug
EUR 459

OAAV00065-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00065-200UG 200ug
EUR 459

OAAV00066-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00066-200UG 200ug
EUR 459

OAAV00067-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00067-200UG 200ug
EUR 459

OAAV00068-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00068-200UG 200ug
EUR 459

Haptoglobin, ID (HP, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (AP)
MBS6308199-02mL 0.2mL
EUR 980

Haptoglobin, ID (HP, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (AP)
MBS6308199-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (PE)
MBS6308209-02mL 0.2mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (PE)
MBS6308209-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (APC)
MBS6308200-02mL 0.2mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (APC)
MBS6308200-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (FITC)
MBS6308202-02mL 0.2mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (FITC)
MBS6308202-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Biotin)
MBS6308201-02mL 0.2mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Biotin)
MBS6308201-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Azide free) (HRP)
MBS6308203-02mL 0.2mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Azide free) (HRP)
MBS6308203-5x02mL 5x0.2mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 405)
MBS6308204-01mL 0.1mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 405)
MBS6308204-5x01mL 5x0.1mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 490)
MBS6308205-01mL 0.1mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 490)
MBS6308205-5x01mL 5x0.1mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 550)
MBS6308206-01mL 0.1mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 550)
MBS6308206-5x01mL 5x0.1mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 650)
MBS6308207-01mL 0.1mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 650)
MBS6308207-5x01mL 5x0.1mL
EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 750)
MBS6308208-01mL 0.1mL
EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 750)
MBS6308208-5x01mL 5x0.1mL
EUR 4250

3`UTR clone of haptoglobin-related protein (HPR) for miRNA target validation
SC201711 10 µg Ask for price

Haptoglobin Human (Haptoglobin Human)
PT_40803
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  • 200 µg
  • 1 mg
  • 10 mg

3`UTR clone of haptoglobin (HP) transcript variant 1 for miRNA target validation
SC202159 10 µg Ask for price

3`UTR clone of haptoglobin (HP) transcript variant 2 for miRNA target validation
SC202160 10 µg Ask for price

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (AP)
MBS6479474-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (AP)
MBS6479474-5x02mL 5x0.2mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (PE)
MBS6479484-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (PE)
MBS6479484-5x02mL 5x0.2mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (APC)
MBS6479475-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (APC)
MBS6479475-5x02mL 5x0.2mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Biotin)
MBS6479476-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Biotin)
MBS6479476-5x02mL 5x0.2mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (FITC)
MBS6479477-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (FITC)
MBS6479477-5x02mL 5x0.2mL
EUR 4250

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-100mL 100 mL
EUR 59.28

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-1Liter 1 Liter
EUR 178.6

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Azide free) (HRP)
MBS6479478-02mL 0.2mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Azide free) (HRP)
MBS6479478-5x02mL 5x0.2mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 405)
MBS6479479-01mL 0.1mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 405)
MBS6479479-5x01mL 5x0.1mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 490)
MBS6479480-01mL 0.1mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 490)
MBS6479480-5x01mL 5x0.1mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 550)
MBS6479481-01mL 0.1mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 550)
MBS6479481-5x01mL 5x0.1mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 650)
MBS6479482-01mL 0.1mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 650)
MBS6479482-5x01mL 5x0.1mL
EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 750)
MBS6479483-01mL 0.1mL
EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 750)
MBS6479483-5x01mL 5x0.1mL
EUR 4250

Haptoglobin Human Recombinant (Haptoglobin Human)
PT_40804
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  • Ask for price
  • Ask for price
  • 5 µg
  • 20 µg
  • 1 mg

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308899 100 µl Ask for price

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308900 100 µl Ask for price

OPPA01435-200UG - Haptoglobin Human - Human Haptoglobin Protein
OPPA01435-200UG 200ug
EUR 112

Haptamide B
MBS5775214-5mg 5(mg
EUR 915

Haptamide B
MBS5775214-5x5mg 5x5(mg
EUR 3970

Haptamide B
T25488-10mg 10mg Ask for price
Description: Haptamide B

Haptamide B
T25488-1g 1g Ask for price
Description: Haptamide B

Haptamide B
T25488-1mg 1mg Ask for price
Description: Haptamide B

Haptamide B
T25488-50mg 50mg Ask for price
Description: Haptamide B

Haptamide B
T25488-5mg 5mg Ask for price
Description: Haptamide B

Haptoglobin
AP78677 1mg
EUR 2640

Hp | Haptoglobin
AS10-1312 1 mg
EUR 233

Haptoglobin
AP83683 1mg
EUR 2640

Haptoglobin
AP83875 1mg
EUR 2640

Haptoglobin
AP83959 1mg
EUR 2640

Haptoglobin
AP84082 1mg
EUR 2640

Haptoglobin
AP84671 1mg
EUR 2640

Haptoglobin
E8ET1703-24 100ul
EUR 275
Description: Available in various conjugation types.

Haptoglobin
E8M1510-36 100ul
EUR 275
Description: Available in various conjugation types.

Haptoglobin
E8M1510-37 100ul
EUR 275
Description: Available in various conjugation types.

Haptoglobin
MBS634332-1mg 1mg
EUR 370

Haptoglobin
MBS634332-5x1mg 5x1mg
EUR 1505

Haptoglobin
MBS8534427-01mL 0.1mL
EUR 345

Haptoglobin
MBS8534427-01mLAF405L 0.1mL(AF405L)
EUR 565

Haptoglobin
MBS8534427-01mLAF405S 0.1mL(AF405S)
EUR 565

Haptoglobin
MBS8534427-01mLAF610 0.1mL(AF610)
EUR 565

Haptoglobin
MBS8534427-01mLAF635 0.1mL(AF635)
EUR 565

Haptoglobin
MBS8534644-01mL 0.1mL
EUR 345

Haptoglobin
MBS8534644-01mLAF405L 0.1mL(AF405L)
EUR 565

Haptoglobin
MBS8534644-01mLAF405S 0.1mL(AF405S)
EUR 565

Haptoglobin
MBS8534644-01mLAF610 0.1mL(AF610)
EUR 565

Haptoglobin
MBS8534644-01mLAF635 0.1mL(AF635)
EUR 565

Haptoglobin
MBS8534645-01mL 0.1mL
EUR 345

Haptoglobin
MBS8534645-01mLAF405L 0.1mL(AF405L)
EUR 565

Haptoglobin
MBS8534645-01mLAF405S 0.1mL(AF405S)
EUR 565

Haptoglobin
MBS8534645-01mLAF610 0.1mL(AF610)
EUR 565

Haptoglobin
MBS8534645-01mLAF635 0.1mL(AF635)
EUR 565

Haptoglobin
MBS8534646-01mL 0.1mL
EUR 305

Haptoglobin
MBS8534646-01mLAF405L 0.1mL(AF405L)
EUR 565

Haptoglobin
MBS8534646-01mLAF405S 0.1mL(AF405S)
EUR 565

Haptoglobin
MBS8534646-01mLAF610 0.1mL(AF610)
EUR 565