Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab.

Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.

Individual Reaction Mix 3
G065-3 200 reactions
EUR 167

3-D Life Thioglycerol
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Dr. P Kit-Solution 3
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EUR 133
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

3-D Life RGD Peptide
P10-3 3x 1 µmol
EUR 276

Recombinant Human MMP-3 Protein
PROTP08254-3 10ug
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Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D-Life SG-PVA
M81-3 3x 170 µl
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3-D Life FG-PVA
M82-3 3x 170 µl
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3-D Life SG-Dextran
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3-D Life PEG-Link
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pLenti-CARM1 shRNA-3 Plasmid
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pLenti-CTLA4 shRNA-3 Plasmid
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pLenti-FOXM1 shRNA-3 Plasmid
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pLenti-JUN shRNA-3 Plasmid
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Anti-active Caspase-3 Rabbit Monoclonal Antibody
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PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9
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ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein
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EUR 334

Anti-LBP Antibody
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Anti-Fibrinogen alpha chain/FGA Antibody
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Anti-VEGF Receptor 2/Kdr Antibody
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Anti-Cystatin C/Cst3 Antibody
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Anti-IL22 Antibody
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Anti-uPA Receptor/PLAUR Antibody
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Anti-AMPK alpha 1/PRKAA1 Antibody
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Anti-MBL2 Antibody
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Anti-BCMA/Tnfrsf17 Antibody
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Anti-p90RSK (Ab-348) Antibody
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Description: Rabbit Polyclonal p90RSK (Ab-348) Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-RANK/Tnfrsf11a Antibody
A01064-3 100ug/vial
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Anti-CD40L/CD40LG Antibody
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EUR 294

Anti-PXR/NR1I2 Antibody
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Anti-IL12B Antibody
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EUR 334

Anti-Choline Acetyltransferase/CHAT Antibody
A01192-3 100ug/vial
EUR 334

Anti-TAPA1/Cd81 Antibody
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EUR 294

Anti-TrkB/NTRK2 Antibody
A01388-3 100ug/vial
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