Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.
Individual Reaction Mix 3 |
G065-3 |
ABM |
200 reactions |
EUR 167 |
3-D Life Thioglycerol |
T10-3 |
Cellendes |
180 µl |
EUR 48 |
Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm |
B1200-3 |
MTC Bio |
5/pack |
EUR 63.77 |
Description: Western Blot Boxes |
TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant |
PROTP10600-3 |
BosterBio |
Regular: 5ug |
EUR 317 |
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques. |
Dr. P Kit-Solution 3 |
K2021010-3 |
Biochain |
50 ml |
EUR 133 |
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
3-D Life RGD Peptide |
P10-3 |
Cellendes |
3x 1 µmol |
EUR 276 |
Recombinant Human MMP-3 Protein |
PROTP08254-3 |
BosterBio |
10ug |
EUR 317 |
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids). |
3-D-Life SG-PVA |
M81-3 |
Cellendes |
3x 170 µl |
EUR 148 |
3-D Life FG-PVA |
M82-3 |
Cellendes |
3x 170 µl |
EUR 148 |
3-D Life SG-Dextran |
M91-3 |
Cellendes |
3x 170 µl |
EUR 157 |
3-D Life FG-Dextran |
M92-3 |
Cellendes |
3x 170 µl |
EUR 157 |
3-D Life PEG-Link |
L50-3 |
Cellendes |
3x 200 µl |
EUR 94 |
3-D Life CD-Link |
L60-3 |
Cellendes |
3 x 200 µl |
EUR 321 |
FSH (Human Follicle-stimulating hormone) ELISA test |
3 |
Biobase |
96T/Box |
Ask for price |
- Area of application: Hormone testing
|
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone) |
Anti-VEGF Receptor 3/FLT4 Antibody |
A01276-3 |
BosterBio |
100ug/vial |
EUR 334 |
Caspase-3 Inhibitor Q-DEVD-OPh |
1175-3 |
Biovision |
|
EUR 533 |
3-D Life Scrambled RGD Peptide |
P11-3 |
Cellendes |
3x 1 µmol |
EUR 276 |
Anti-active Caspase-3 Rabbit Monoclonal Antibody |
M00334-3 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human |
Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12) |
M00621-3 |
BosterBio |
100ug/vial |
EUR 334 |
QuantiMir 3'-Universal Primer (10,000 qPCR reactions) |
RA420AU-3 |
SBI |
10,000 assays |
EUR 178 |
|
SeraMir 3'-Universal Primer (10,000 qPCR reactions) |
RA800P-3 |
SBI |
10,000 reactions |
EUR 178 |
|
3-D Life 10x CB Buffer (pH 7.2) |
B20-3 |
Cellendes |
600 µL |
EUR 44 |
3-D Life 10x CB-Buffer (pH 5.5) |
B10-3 |
Cellendes |
600 µl |
EUR 44 |
Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit |
30009-3 |
Biotium |
1KIT |
EUR 809 |
Description: Minimum order quantity: 1 unit of 1KIT |
Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody |
M00227-3 |
BosterBio |
100ul |
EUR 397 |
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine. |
PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9 |
PROTP49763-3 |
BosterBio |
Regular: 25ug |
EUR 317 |
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques. |
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions) |
M1030-3 |
Biovision |
|
EUR 441 |
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions) |
M1031-3 |
Biovision |
|
EUR 436 |
TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions) |
M1032-3 |
Biovision |
|
EUR 436 |
TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions) |
M1033-3 |
Biovision |
|
EUR 436 |
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions) |
M1034-3 |
Biovision |
|
EUR 332 |
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions) |
M1035-3 |
Biovision |
|
EUR 430 |
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions) |
M1036-3 |
Biovision |
|
EUR 430 |
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions) |
M1037-3 |
Biovision |
|
EUR 430 |
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions) |
M1039-3 |
Biovision |
|
EUR 436 |
ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein |
PROTQ9Y5C1-3 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions).  |
Lethal factor Protease Substrate 3, AMC derivative MEk2 peptide substrate for high-throughput screening of LF inhibitors (14aa) |
LFPS-3 |
Alpha Diagnostics |
1 mg |
EUR 408 |
Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #3) |
PEG13-M-3 |
Alpha Diagnostics |
100 ug |
EUR 482 |
Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #3) |
CDTA12-M-3 |
Alpha Diagnostics |
100 ug |
EUR 482 |
ABC diluent buffer |
AR1106-3 |
BosterBio |
12ml |
EUR 91 |
cDNA from Congenital heart disease: Heart |
C1236122Hd-3 |
Biochain |
40 reactions |
EUR 668 |
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
cDNA from Emphysema: Lung |
C1236152Ld-3 |
Biochain |
40 reactions |
EUR 811 |
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
BioMagPlus Concanavalin A |
BP531-3 |
Bangs Laboratories |
3 ml |
EUR 518.29 |
Description: BioMagPlus Concanavalin A is magnetic particles with affinity binding proteins may be coated with the primary antibody or biotinylated molecule |
Goat anti-mouse IgG (γ chain specific)-HRP |
E22NM02-3 |
EnoGene |
100ul |
EUR 343 |
Efficiency Box refill (anti-rabbit) |
EB-3 |
Detroit R&D |
27 vials |
EUR 101 |
Rev-A3-GFP/Luc HIV Reporter Cells |
HRC-3 |
101Bio |
NULL |
EUR 0 |
Anti-Human CD45 Monoclonal Antibody Unconjugated Conjugated, Flow Validated |
FC00555-3 |
BosterBio |
Various Sizes |
EUR 101 |
Description: Mouse Monoclonal Human CD45 Antibody Unconjugated Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
Empty FPLC 8ml Columns |
FPLC8-3 |
ABTBeads |
3/pk |
EUR 99 |
Extension of On-going custom antibody Order form |
Ext-3 |
Alpha Diagnostics |
1 |
Ask for price |
Anti-TNF alpha Antibody |
A00002-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-p16 Monoclonal Antibody |
A00016-3 |
BosterBio |
100ul |
EUR 397 |
Description: Mouse Monoclonal Antibody for p16 Antibody (CDKN2A) detection. Tested with WB, IHC in Human, Mouse, Rat. |
Anti-APP/C99 Antibody |
A00081-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-IL1 beta Antibody |
A00101-3 |
BosterBio |
100ug |
EUR 455 |
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat. |
Anti-IL-6 Antibody |
A00102-3 |
BosterBio |
1mL |
EUR 1232 |
Description: Rabbit Polyclonal IL-6 Antibody. Validated in IP, WB and tested in Human. |
Anti-Nanog Antibody |
A00153-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-IL17C Antibody |
A00164-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Flt3/CD135 Antibody |
A00188-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Aryl hydrocarbon Receptor/Ahr Antibody |
A00225-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CRP Antibody Fluorescein Conjugated |
A00249-3 |
BosterBio |
100ug |
EUR 455 |
Description: Goat Polyclonal CRP Antibody Fluorescein Conjugated. Validated in WB and tested in Human. |
Anti-BMAL1/ARNTL Antibody |
A00260-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-AICDA Antibody |
A00267-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-NFkB-p65 (Ab-276) Antibody |
A00284-3 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal NFkB-p65 (Ab-276) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
Anti-ICOS Antibody |
A00291-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TNF Receptor I/TNFRSF1A Antibody |
A00294-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Interferon gamma/IFNG Antibody |
A00393-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TLR1 Antibody |
A00429-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-IGFBP3 Antibody |
A00435-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-TANK Antibody |
A00445-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-beta 2 Microglobulin/B2m Antibody |
A00456-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-FGF23 Antibody |
A00478-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Leptin Antibody |
A00479-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD5 Antibody |
A00480-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-SYK Antibody |
A00490-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-PON1 Antibody |
A00516-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Cytochrome P450 17A1/Cyp17a1 Antibody |
A00615-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-CSF1 Antibody |
A00620-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Polycystin 2/PKD2 Antibody |
A00630-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-IL1RA/Il1rn Antibody |
A00651-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Smad1 (Ab-465) Antibody |
A00728-3 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Smad1 (Ab-465) Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
Anti-LOX 1/Olr1 Antibody |
A00760-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Collagen III/COL3A1 Antibody |
A00788-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-LBP Antibody |
A00809-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Fibrinogen alpha chain/FGA Antibody |
A00816-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-VEGF Receptor 2/Kdr Antibody |
A00901-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Cystatin C/Cst3 Antibody |
A00961-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-IL22 Antibody |
A00963-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-uPA Receptor/PLAUR Antibody |
A00993-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-AMPK alpha 1/PRKAA1 Antibody |
A00994-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-MBL2 Antibody |
A01000-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-BCMA/Tnfrsf17 Antibody |
A01014-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-KCNH1 Antibody |
A01036-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-p90RSK (Ab-348) Antibody |
A01058-3 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal p90RSK (Ab-348) Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
Anti-RANK/Tnfrsf11a Antibody |
A01064-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD40L/CD40LG Antibody |
A01114-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-PXR/NR1I2 Antibody |
A01133-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-IL12B Antibody |
A01152-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Choline Acetyltransferase/CHAT Antibody |
A01192-3 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TAPA1/Cd81 Antibody |
A01281-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-TrkB/NTRK2 Antibody |
A01388-3 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-PRMT1 Antibody |
A01417-3 |
BosterBio |
100ug/vial |
EUR 294 |