Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab.

Immune checkpoint inhibitors (ICIs) represent a major development in cancer treatment, allowing for improved survival and disease control in an expanding number of cancer types. Due to their mechanism of disrupting immunologic homeostasis, ICIs are frequently associated with adverse effects, termed immune related adverse effects (irAE). These side effects can affect any organ system, including the central and peripheral nervous systems. We present a case of a 47 year old man with stage IIIc metastatic melanoma who received 3 cycles of nivolumab (a monoclonalantibody inhibitor of programmed cell death protein 1 (PD-1)). After completing the third cycle, he presented with a meningoencephalitis clinical picture with an inflammatory cerebrospinal fluid (CSF) and normal MRI. He was found to have a positive anti-glial fibrillary acidic protein (GFAP) autoantibody in his CSF by immunofluorescent assay (IFA) and cell based assay (CBA) which confirmed a diagnosis of anti-GFAP autoimmune encephalitis. He was treated with immunotherapy and made a full recovery. In this report, we present the first reported case of anti-GFAP autoimmune encephalitis associated with ICI therapy and provide a brief review of the literature.

HaP-T1
ABC-TC039S	AcceGen	1 vial	Ask for price
Description: Cancer; Lifespan: infinite; Mucin producing, BHP-induced pancreatic tumor.

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-100mL	Diagnopal	100 mL	EUR 59.28

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-1Liter	Diagnopal	1 Liter	EUR 178.6

OAAV00052-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00052-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00053-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00053-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00054-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00054-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00055-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00055-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00056-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00056-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00057-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00057-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00058-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00058-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00059-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00059-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00060-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00060-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00061-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00061-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00062-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00062-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00063-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00063-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00064-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00064-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00065-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00065-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00066-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00066-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00067-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00067-200UG	Aviva Systems Biology	200ug	EUR 459

OAAV00068-200UG - Hapten 4-hydroxy-3-nitrophenyl acetyl (NP) Antibody
OAAV00068-200UG	Aviva Systems Biology	200ug	EUR 459

3`UTR clone of haptoglobin-related protein (HPR) for miRNA target validation
SC201711	Origene Technologies GmbH	10 µg	Ask for price

3`UTR clone of haptoglobin (HP) transcript variant 1 for miRNA target validation
SC202159	Origene Technologies GmbH	10 µg	Ask for price

3`UTR clone of haptoglobin (HP) transcript variant 2 for miRNA target validation
SC202160	Origene Technologies GmbH	10 µg	Ask for price

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308899	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308900	Origene Technologies GmbH	100 µl	Ask for price

Haptamide B
T25488-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-1g	TargetMol Chemicals	1g	Ask for price
Description: Haptamide B

Haptamide B
T25488-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Haptamide B

OPPA01435-200UG - Haptoglobin Human - Human Haptoglobin Protein
OPPA01435-200UG	Aviva Systems Biology	200ug	EUR 112

Haptoglobin
E8ET1703-24	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Haptoglobin
E8M1510-36	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Haptoglobin
E8M1510-37	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Haptoglobin
AP78677	SAB	1mg	EUR 2640

Haptoglobin
AP83683	SAB	1mg	EUR 2640

Haptoglobin
AP83875	SAB	1mg	EUR 2640

Haptoglobin
AP83959	SAB	1mg	EUR 2640

Haptoglobin
AP84082	SAB	1mg	EUR 2640

Haptoglobin
AP84671	SAB	1mg	EUR 2640

Haptoglobin (19-347)
pro-1897	ProSpec Tany	2µg	EUR 60
Description: Recombinant Human Haptoglobin (19-347 a.a)

Haptoglobin
pro-567	ProSpec Tany	5µg	EUR 60
Description: Recombinant Human Haptoglobin

Rat Haptoglobin (Hp)
1-CSB-RP170694r	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rat Haptoglobin(Hp),partial expressed in E.coli

Rat Haptoglobin
8110	Life Diagnostics	0.1 mg	EUR 220

Dog Haptoglobin
8120	Life Diagnostics	0.1 mg	EUR 220

Pig Haptoglobin
8130	Life Diagnostics	0.1 mg	EUR 220

Haptoglobin, Sf9
pro-2586	ProSpec Tany	2µg	EUR 60
Description: Recombinant Human Haptoglobin, Sf9

Human Haptoglobin
7-05311	CHI Scientific	200µg	Ask for price

Human Haptoglobin
7-05312	CHI Scientific	1mg	Ask for price

Human Haptoglobin
7-05313	CHI Scientific	10mg	Ask for price

Mouse Haptoglobin
8140	Life Diagnostics	0.1 mg	EUR 220

Horse Haptoglobin
8150	Life Diagnostics	1 mg	EUR 275

Human Haptoglobin (HP)
1-CSB-EP010691HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Haptoglobin(HP) expressed in E.coli

Haptoglobin Mixed 95%
GWB-D29DCE	GenWay Biotech	2 mg	Ask for price

Haptoglobin Human
rAP-3368	Angio Proteomie	Inquiry	Ask for price

Haptoglobin Assay Kit
abx098432-BeckmanR140ml1R210ml1	Abbexa	Beckman; R1: 40ml×1 R2: 10ml×1	EUR 416.4

Haptoglobin Assay Kit
abx098432-Hitachi7020R140ml1R210ml1	Abbexa	Hitachi 7020; R1: 40ml×1 R2: 10ml×1	EUR 416.4

Haptoglobin Assay Kit
abx098432-Hitachi7170R120ml1R25ml1	Abbexa	Hitachi 7170; R1: 20ml×1 R2: 5ml×1	EUR 322.8

Haptoglobin Assay Kit
abx098432-Toshiba40R140ml1R210ml1	Abbexa	Toshiba 40; R1: 40ml×1 R2: 10ml×1	EUR 416.4

Rabbit Haptoglobin
8175	Life Diagnostics	0.1 mg	EUR 220

Rat Haptoglobin (HP) CLIA Kit
abx195771-96tests	Abbexa	96 tests	EUR 990

Cow Haptoglobin (HP) CLIA Kit
20-abx492072	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Bovine Haptoglobin
8010	Life Diagnostics	1 mg	EUR 880

Haptoglobin ELISA kit
55R-1873	Fitzgerald	1 kit	EUR 891.6
Description: ELISA kit for the detection of Haptoglobin in the research laboratory

Haptoglobin ELISA, Rat
KT-190	Kamiya Biomedical Company	96 tests	EUR 506

Haptoglobin, Bovine
KT-191	Kamiya Biomedical Company	1 kit	EUR 506

Pig Haptoglobin ELISA
KT-349	Kamiya Biomedical Company	1 kit	EUR 506

Cat Haptoglobin ELISA
KT-422	Kamiya Biomedical Company	96 tests	EUR 537

Haptoglobin Mouse mAb
E2M50010	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat HP -Haptoglobin- CLIA Kit
E-CL-R0320-24Tests	Elabscience Biotech	24 Tests	EUR 180
Description: Sandwich

Rat HP -Haptoglobin- CLIA Kit
E-CL-R0320-48Tests	Elabscience Biotech	48 Tests	EUR 546
Description: Sandwich

Rat HP -Haptoglobin- CLIA Kit
E-CL-R0320-96Tests	Elabscience Biotech	96 Tests	EUR 682
Description: Sandwich

Rat HP -Haptoglobin- CLIA Kit
E-CL-R0320-96Tests10	Elabscience Biotech	96 Tests *10	EUR 6820
Description: Sandwich

Rat HP -Haptoglobin- CLIA Kit
E-CL-R0320-96Tests5	Elabscience Biotech	96 Tests *5	EUR 3410
Description: Sandwich

Haptoglobin ELISA Kit
80714	Crystal Chem	96	EUR 425

(19-347) Haptoglobin (19-347 a.a) Human Recombinant Protein
PROTP00738-2	BosterBio	Regular: 10ug	EUR 380.4
Description: Haptoglobin Human Recombinant produced in E. coli is a single polypeptide chain containing 352 amino acids (19-347) and having a molecular mass of 39.0 kDa. Haptoglobin is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Haptoglobin Rabbit mAb
59347	SAB	100ul	EUR 339

Rat Haptoglobin (HP) ELISA Kit
abx051814-96tests	Abbexa	96 tests	EUR 904.8

Pig Haptoglobin (HP) ELISA Kit
abx051815-96tests	Abbexa	96 tests	EUR 943.2

Haptoglobin (HP) Rabbit mAb
A8778	Abclonal	200μL	EUR 1557.4
Description: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RNF20 (Q5VTR2).

Haptoglobin protein
30-AH02	Fitzgerald	1 mg	EUR 144
Description: Purified native Human Haptoglobin protein

Haptoglobin protein
30C-CP3018	Fitzgerald	1 mg	EUR 180
Description: Purified native Human Haptoglobin protein

Pig Haptoglobin (HP) ELISA Kit
abx255484-96tests	Abbexa	96 tests	EUR 943.2

Rat Haptoglobin (HP) ELISA Kit
abx256353-96tests	Abbexa	96 tests	EUR 904.8

Haptoglobin (19-347 a.a) Protein
20-abx262754	Abbexa	Ask for price Ask for price Ask for price	10 ug 1 mg 2 µg

Haptoglobin Protein
20-abx260629	Abbexa	Ask for price Ask for price Ask for price	1 mg 20 ug 5 ug

Dog Haptoglobin (HP) ELISA Kit
abx250008-96tests	Abbexa	96 tests	EUR 1036.8

Pig Haptoglobin (HP) ELISA Kit
abx514090-96tests	Abbexa	96 tests	EUR 943.2

Rat Haptoglobin (HP) ELISA Kit
abx514091-96tests	Abbexa	96 tests	EUR 904.8

Cow Haptoglobin (HP) ELISA Kit
20-abx257182	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Cow Haptoglobin (HP) ELISA Kit
20-abx258067	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Haptoglobin Protein
20-abx260046	Abbexa	Ask for price Ask for price Ask for price	10 mg 1 mg 200 ug

Dog Haptoglobin (Hpt) CLIA Kit
20-abx492073	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Pig Haptoglobin (Hpt) CLIA Kit
20-abx492075	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Rat Haptoglobin (Hpt) CLIA Kit
20-abx492076	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

CLIA kit for Rat HP (Haptoglobin)
E-CL-R0320	Elabscience Biotech	1 plate of 96 wells	EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat HP (Haptoglobin) in samples from Serum, Plasma, Cell supernatant

Cat Haptoglobin ELISA Kit
E-20HPT	Immunology Consultants Laboratory	1 x 96 well plate	EUR 553.2

Dog Haptoglobin ELISA Kit
E-40HPT	Immunology Consultants Laboratory	1 x 96 well plate	EUR 529.2

Dog HP/ Haptoglobin ELISA Kit
E0046Do	Sunlong	1 Kit	EUR 630
Description: Zonulin

Pig HP/ Haptoglobin ELISA Kit
E0087Pi	Sunlong	1 Kit	EUR 630
Description: Zonulin

Rat Haptoglobin ELISA kit
E02H0104-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Haptoglobin ELISA kit
E02H0104-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Haptoglobin ELISA kit
E02H0104-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Hp/ Haptoglobin ELISA Kit
E0462Ra	Sunlong	1 Kit	EUR 557
Description: Ba1-647,Liver regeneration-related protein LRRG173,Zonulin

Dog Haptoglobin ELISA kit
E08H0104-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Haptoglobin ELISA kit
E08H0104-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Haptoglobin ELISA kit
E08H0104-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Haptoglobin ELISA kit
E07H0104-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Haptoglobin ELISA kit
E07H0104-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Haptoglobin ELISA kit
E07H0104-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Haptoglobin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.