The First-in-Human Study of CNTO 7160, an Anti-Interleukin-33 Receptor Monoclonal Antibody, in Healthy Subjects and Patients with Asthma or Atopic Dermatitis.

NTO 7160 was generally well tolerated, with one serious adverse event of severe cellulitis reported (AD, CNTO 7160 3 mg kg-1 ). CNTO 7160 exhibited non-linear PK (0.01 to 10 mg kg-1 ). Mean clearance decreased with increasing dose (2.43 to 18.03 mL day-1 kg-1 ). CNTO 7160 PK was similar between healthy subjects and patients with asthma or AD (3 or 10 mg kg-1 ). Free sIL-33R suppression was rapid and dose-dependent. Ex-vivo inhibition of p38 phosphorylation of basophils was dose-dependent (1 to 10 mg kg-1 ) and sustained inhibition (≥75%) was observed at higher doses (3 or 10 mg kg-1 ). PK/PD modelling and simulation suggests that 1 mg/kg IV every 2 weeks provides adequate systemic drug exposure for sustained inhibition of p38 phosphorylation of basophils.

Despite confirmation of target engagement, no apparent CNTO 7160 clinical activity was observed in patients (asthma or AD).This first-in-human study provides PK, PD, and safety data, supporting further clinical investigation of CNTO 7160 in patients with asthma and AD.

pLenti-CLDN1 shRNA-4 Plasmid

PVTBAV04867-4 2 ug
EUR 356

Feline IL-4 Recombinant Protein

R00230-4 5ug/vial
EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Mouse FibrOut 4, for brain, neural

4-20507 1 ml Ask for price

Mouse FibrOut 4, for brain, neural

4-20508 5 x 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20533 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20534 5 x 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 120V

6780-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Bone Dissociation System 4 (Osteoblasts), Adult Mouse

4-20214 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse

4-20404 ea Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat

4-20444 ea Ask for price

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat

4-20234 ea Ask for price

Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse

4-20324 ea Ask for price

Pancreas Dissociation System 4 (Islets), Mouse and Rat

4-20374 ea Ask for price

Skin Dissociation System 4 (Keratinocytes), Mouse and Rat

4-20434 ea Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG

6781-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG

6782-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Adipose/Fat Dissociation System 4 (Predipocytes), Mouse and Rat

4-20194 ea Ask for price

Brain Dissociation System 4 (Endothelial, Microvessels), Mouse and Rat

4-20224 ea Ask for price

Endothelial Dissociation System 4 (Endothelial,Cerebral), Mouse and Rat

4-20244 ea Ask for price

Heart Dissociation System 4 (Myocytes,Ventricles), Mouse and Rat

4-20274 ea Ask for price

Muscle Dissociation System 4 (Smooth muscle), Mouse and Rat

4-20334 ea Ask for price

Parotid Dissociation System 4 (Parotid acinar), Mouse and Rat

4-20394 ea Ask for price

Epithelial Dissociation System 4 (Epithelial,Submandibular salivary), Mouse and Rat

4-20254 ea Ask for price

Heart Dissociation System 4 (Retinal pigment epithelial), Mouse and Rat

4-20294 ea Ask for price

Lung Dissociation System 4 (Alveolar type II), Mouse and Rat

4-20314 ea Ask for price

Reproductive Tissue Dissociation System 4 (Epithelial, vagina), Mouse and Rat

4-20414 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials)

M1040-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials)

M1041-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials)

M1042-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials)

M1043-4
EUR 1132

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials)

M1046-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials)

M1047-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 4 vials)

M1054-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 4 vials)

M1055-4
EUR 1142

Adrenal Dissociation System 4 (Heart, Adrenal chromaffin, Paraneurons), Mouse and Rat

4-20204 ea Ask for price

Kidney Dissociation System 4 (Inner medullary duct,Papillae), Mouse and Rat

4-29294 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 4 vials)

M1048-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 4 vials)

M1049-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 4 vials)

M1050-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 4 vials)

M1051-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 4 vials)

M1052-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 4 vials)

M1053-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 4 vials)

M1058-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 4 vials)

M1059-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 4 vials)

M1060-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 4 vials)

M1061-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 4 vials)

M1064-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 4 vials)

M1065-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 4 vials)

M1066-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 4 vials)

M1067-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 4 vials)

M1070-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, B16F10 cell line, 4 vials)

M1071-4
EUR 1142

Tumor Dissociation System 4 (Epithelial tumor,Neoplastic, Tumor, islet), Mouse and Rat

4-20484 ea Ask for price

ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 4 vials)

M1062-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 4 vials)

M1063-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 4 vials)

M1068-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 4 vials)

M1069-4
EUR 1142

ExoStd? Lyophilized Exosome Standard (30 µg, SK-N-SH cell line, 4 vials)

M1056-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, SK-N-SH cell line, 4 vials)

M1057-4
EUR 1142

Neural Dissociation System 4 (Cerebella neurons Dorsa horn neurons Neurons, sympathetic Precursor Spinal), Mouse and Rat

4-20354 ea Ask for price

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

DLR-CA72-4-Hu-48T 48T
EUR 479
  • Should the Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

DLR-CA72-4-Hu-96T 96T
EUR 621
  • Should the Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RD-CA72-4-Hu-48Tests 48 Tests
EUR 478

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RD-CA72-4-Hu-96Tests 96 Tests
EUR 662

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RDR-CA72-4-Hu-48Tests 48 Tests
EUR 500

Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit

RDR-CA72-4-Hu-96Tests 96 Tests
EUR 692

PRL (Prolactin) ELISA test

4 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of PRL (Prolactin)

Graduated Plastic Cylinders, 1000ml

CD001-4 1 UNIT
EUR 63.05
  • Product category: Labware/Cylinders/1000ml

Graduated Plastic Beakers, 250ml

BK044-4 1 UNIT
EUR 53.05
  • Product category: Labware/Beakers/250ml

cDNA from Arteriosclerosis: Aorta

C1236012Hd-4 40 reactions
EUR 811
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Arteriosclerosis: Artery

C1236013Hd-4 40 reactions
EUR 811
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Pneumonia: Lung

C1236152Ld-4 40 reactions
EUR 811
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

rabbit anti-mouse IgG (H+L)

E22NM02-4 100ug
EUR 343

Efficiency Box refill (anti-goat)

EB-4 27 vials
EUR 101

Rev-CEM-GFP HIV Reporter Cells

HRC-4 NULL
EUR 0

ExoMS Surface Protein Capture Kit (Serum/Plasma EVs)

EXOMS100A-4 4 reactions
EUR 539
  • Category: Exosomes

ExoMS Surface Protein Capture Kit (Tissue Culture EVs)

EXOMS110A-4 4 reactions
EUR 539
  • Category: Exosomes

Exo-Check Exosome Antibody Array

EXORAY200A-4 4 arrays
EUR 540

Exo-Check Exosome Antibody Array (Neuro) Standard

EXORAY500A-4 4 arrays
EUR 690

Exo-Check Exosome Antibody Array (Neuro) Mini

EXORAY510A-4 4 arrays
EUR 467

Anti-CCL2 Antibody

A00056-4 100ug/vial
EUR 294

Anti-CCR2 Antibody

A00158-4 100ug/vial
EUR 294

Anti-Flt3/CD135 Antibody

A00188-4 100ug/vial
EUR 334

Anti-C Reactive Protein/CRP Antibody

A00249-4 100ug/vial
EUR 334

Anti-Leptin Antibody

A00479-4 100ug/vial
EUR 334

Anti-CD5 Antibody

A00480-4 100ug/vial
EUR 334

Anti-IL1RA/Il1rn Antibody

A00651-4 100ug/vial
EUR 294

Anti-VEGFR2 (Ab-1214) Antibody

A00901-4 100ul
EUR 397
Description: Rabbit Polyclonal VEGFR2 (Ab-1214) Antibody. Validated in IF, IHC and tested in Human, Mouse, Rat.

Anti-IL12B Antibody

A01152-4 100ug/vial
EUR 294

Anti-Choline Acetyltransferase/CHAT Antibody

A01192-4 100ug/vial
EUR 334

Anti-HDAC5 (Ab-498) Antibody

A01230-4 100ul
EUR 397
Description: Rabbit Polyclonal HDAC5 (Ab-498) Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-ADAM15 Antibody

A02593-4 100ug/vial
EUR 294

Anti-HE4/WFDC2 Antibody

A02685-4 100ug/vial
EUR 334

Anti-MORC3 Antibody

A06075-4 100ug/vial
EUR 334

3X FLAG Peptide

A6001-4 4 mg
EUR 154
Description: The FLAG-tag system utilizes a short, hydrophilic 8- amino-acid peptide that is fused to the protein of interest1. The FLAG peptide binds to the antibody M1. Whether binding is calcium-dependent manner2 or ?independent3 remains controversial.

FLAG tag Peptide

A6002-4 4 mg
EUR 131
Description: A fusion tag called FLAG and consisting of eight amino acids Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys including an enterokinase-cleavage site, was specifically designed for immunoaffinity chromatography. It allows elution under non-denaturing conditions.

Adipose/Fat Dissociation System 1 (Brown fat Adipose), Mouse and Rat

4-20191 ea Ask for price

Adipose/Fat Dissociation System 2 (White Fat, Vascular endothelial, Epididymal Fat, pads Fat), Mouse and Rat

4-20192 ea Ask for price

Adipose/Fat Dissociation System 3 (Adipocytes), Mouse and Rat

4-20193 ea Ask for price

Adipose/Fat Dissociation System 5 (Brown adipocytes, Interscapular depots, Cervical depot), Mouse and Rat

4-20195 ea Ask for price

Adrenal Dissociation System 1 (ZG,ZFR), Mouse and Rat

4-20201 ea Ask for price

Adrenal Dissociation System 2 (Leydig, Adrenal), Mouse and Rat

4-20202 ea Ask for price

Adrenal Dissociation System 3 (Adrenocortical), Mouse and Rat

4-20203 ea Ask for price

Adrenal Dissociation System 5 (Adrenocortical, Decapular, Capsular, Glomerulosa), Mouse and Rat

4-20205 ea Ask for price

Adrenal Dissociation System 6 (Chromaffin, Endothelial, Glomerulosa), Mouse and Rat

4-20206 ea Ask for price

Adrenal Dissociation System 7 (Medullary), Mouse and Rat

4-20207 ea Ask for price

Adrenal Dissociation System 8 (Cortical), Mouse and Rat

4-20208 ea Ask for price

Adrenal Dissociation System 9 (Adrenal), Mouse and Rat

4-20209 ea Ask for price

Bone Dissociation System 1 (Chondrocytes, Neonatal bone, Osteoblastlike cells), Mouse and Rat

4-20211 ea Ask for price

Bone Dissociation System 2 (Osteoblasts, Chondrocytes), Mouse and Rat

4-20212 ea Ask for price

Bone Dissociation System 3 (Vertebrae chondroblasts), Mouse and Rat

4-20213 ea Ask for price

Bone Dissociation System 5 (Osteoblasts), Rat

4-20215 ea Ask for price

Bone Dissociation System 6 (Osteoblasts), Mouse 6-8 weeks

4-20216 ea Ask for price

Bone Dissociation System 7 (Osteoblastlike cells, Stromal cells, Hematopietic blast cells), Mouse and Rat

4-20217 ea Ask for price

Brain Dissociation System 1 (Astrocytes, Glial, Cerebral cortices, Germinal matrix, Hippocampi, Neural), Mouse and Rat

4-20221 ea Ask for price

Brain Dissociation System 2 (Glial, Schwann), Mouse and Rat

4-20222 ea Ask for price

Brain Dissociation System 3 (Hippocampal neurons), Mouse and Rat

4-20223 ea Ask for price

Brain Dissociation System 5 (Cerebral cortex), Mouse and Rat

4-20225 ea Ask for price

Brain Dissociation System 6 (Brain), Fetal Rat

4-20226 ea Ask for price

Brain Dissociation System 7 (Endothelial), Mouse and Rat

4-20227 ea Ask for price

Brain Dissociation System 8 (Capillary endothelium, Pericytes), Mouse and Rat

4-20228 ea Ask for price

Cartilage Dissociation System 1 (Mesenchymal, Fibroblasts, Epithelial-like), Mouse and Rat

4-20231 ea Ask for price

Cartilage Dissociation System 2 (Articular cartilage, Chondrocytes, Matrix vesicles, Wing buds), Mouse and Rat

4-20232 ea Ask for price

Cartilage Dissociation System 3 (Articular chondrocytes, Chondrocytes), Mouse and Rat

4-20233 ea Ask for price

Endothelial Dissociation System 1 (Smooth muscle, arota), Mouse and Rat

4-20241 ea Ask for price

Endothelial Dissociation System 2 (Endothelial, Kupffer, Lipocytes, Sinusoidal endothelial), Mouse and Rat

4-20242 ea Ask for price

Endothelial Dissociation System 3 (Endothelial, Kupffer, Parenchymal), Mouse and Rat

4-20243 ea Ask for price

Endothelial Dissociation System 5 (Endothelial,Thoracic aorta), Mouse and Rat

4-20245 ea Ask for price

Endothelial Dissociation System 6 (Endothelial), Mouse and Rat

4-20246 ea Ask for price

Endothelial Dissociation System 7 (Cerebrovascular endothelial), Mouse and Rat

4-20247 ea Ask for price

Epithelial Dissociation System 1 (Intestinal mesenchymal and epithelial,Liver epithelial,Mammary epithelial), Mouse and Rat

4-20251 ea Ask for price

Epithelial Dissociation System 2 (Epididymal epithelial, Gastric parietal and chief Submandibular salivary), Mouse and Rat

4-20252 ea Ask for price

Epithelial Dissociation System 3 (Epithelial, < 10-day-old rat, Epithelial-like, Esophageal, Uterine), Rat

4-20253 ea Ask for price

Epithelial Dissociation System 5 (Epithelial, Interlobular duct fragments), Mouse and Rat

4-20255 ea Ask for price

Epithelial Dissociation System 6 (Gastric epithelial), Mouse and Rat

4-20256 ea Ask for price

Epithelial Dissociation System 7 (Colon, Trachea), Mouse and Rat

4-20257 ea Ask for price

Epithelial Dissociation System 8 (Uterine), Mouse and Rat

4-20258 ea Ask for price

Epithelial Dissociation System 9 (Mesothelial and surface epithelial, Ovaries), Mouse and Rat

4-20259 ea Ask for price

Epithelial Dissociation System 10 (Stomach epithelial), Mouse and Rat

4-20260 ea Ask for price

Epithelial Dissociation System 11 (Epithelial Cells), Mouse and Rat

4-20261 ea Ask for price

Epithelial Dissociation System 12 (Esophagus epithelial), Mouse and Rat

4-20262 ea Ask for price

Epithelial Dissociation System 13 (Colon, Intestinal epithelial), Mouse and Rat

4-20263 ea Ask for price

Heart Dissociation System 1 (Myocytes), Mouse and Rat

4-20271 ea Ask for price